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Signs and symptoms of NF2 usually result from the development of benign, slow-growing tumors in both ears (acoustic neuromas), which can cause hearing loss. It is diagnosed by having 6 or more light brown spots on the skin (café-au-lait spots) greater than 5mm in diameter before puberty. Instead, patients with this disease have: intracranial schwannoma(s): mostly vestibular schwannoma(s) sometimes patients may have spinal schwannomas What is neurofibromatosis type 1 (NF1)? Neurofibromatoses (NF) comprise a number of clinically and genetically distinct inherited conditions that carry a high risk of tumor formation.They fall under the wider classification of phakomatoses.The tumors particularly involve the central and peripheral nervous systems: neurofibromatosis type 1 Neurofibromatosis 2. Neurofibromatosis type 2 (NF2) is a rare autosomal dominant neurocutaneous disorder (phakomatosis) manifesting as a development of multiple CNS tumors.Unlike neurofibromatosis type 1 (NF1), it is not associated with neurofibromas. Most kids with NF1 have mild symptoms that don't limit what they can do. NF2 may often be confused with NF1. Besides NF2, there are two other distinct forms of neurofibromatosis: neurofibromatosis type 1 (NF1) and schwannomatosis. Learning disabilities are present in at least 50% of individuals with NF1. It causes benign (not cancerous) tumors to grow in and under the skin, often with bone, hormone, and other problems. Neurofibromatosis type 2 (NF2) is a hereditary condition most commonly associated with bilateral vestibular schwannomas, also known as acoustic neuromas. There are two main types of neurofibromatosis: NF1: The most common type, it affects 1 of every 3,000 births. Like NF2, NF1 is also a genetic disorder characterized by the presence of tumors that form along nerves in the body. Neurofibromatosis type 1 (NF1) is a genetic condition. These are benign (noncancerous) tumors that occur on the nerves for balance and hearing leading to the inner ear. Although these tumors are benign, they can cause hearing and balance problems. Neurofibromatosis 2 (NF2) is much less common than NF1. It is caused by loss-of-function (LoF) mutations in a single gene — NF1 (for … Neurofibromatosis 1 (NF1) is characterized by multiple café-au-lait spots, axillary and inguinal freckling, multiple cutaneous neurofibromas, and iris Lisch nodules. Neurofibromatosis Type 1 (NF1) is a genetic disorder (incidence 1:3000) that causes tumors (neurofibromas) to grow along nerves in the skin, brain, and other parts of the body.