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T cell responses are downregulated by CTLA-4 and Fas Here, we discuss a novel function of IL-6: the … Interleukin (IL)-6 is a cytokine produced by several cell types including antigen presenting cells (APC) such as macrophages, dendritic cells, and B cells. subsequent activation by antigen . IL-6 is involved in the acute phase response, B cell maturation, and macrophage differentiation. To investigate further the two most prominent NFAT family members, NFATc1 and NFATc2, we generated mice bearing lymphoid systems devoid of both. T-cell activation. During this priming, the T-cell and APC bind through various adhesion molecules, which initiate 2 signals inside the T-cell that make it differentiate and proliferate into effector and memory T-cells. Learn vocabulary, terms, and more with flashcards, games, and other study tools. • There are actually two related molecules: B7.1 and B7.2 Expressed after T cell activation Expressed in resting and activated T cells Signal 2 They specifically mature and differentiate into distinct types of T cells while in the gland before migrating to the periphery. (If T cells receive signal 2 only, nothing happens.)
- If T cells receive signal 1 and signal 2, they will be activated to participate in an immune response to the antigen. after T cell activation. • Interaction of CTLA-4 with B7 is thought to down-regulate T cell activation. View Chapter_10_T-cell_Maturation_Activation_and_Differentiation from CD 4 at Northeastern University. B-cell Maturation, Activation, and Differentiation - Biology 362 with Arterburn/bjerke at Washburn University - … T cell activation requires 2 signals: TCR and costimulation. In secondary lymphoid organs, naïve T cells are activated by mature dendritic cells. T cells originate from hematopoietic stem cells in the bone marrow as precursor cells, and they migrate to the thymus to develop further. • CTLA-4 has a higher affinity for B7 than CD28 . Lack of costimulation during T cell activation leads to anergy. The process when a T-cell first encounters the antigen presented by an APC is called priming. Naive T cells leave the thymus and enter secondary lymphoid organs. NFAT transcription factors play critical roles in gene transcription during immune responses. Start studying Immunology: T Cell Development, Activation, and Differentiation. Production, Activation, and Differentiation: The Major Types of T Cells. T cells migrate from the bone marrow to the thymus where they become CD4-CD8-(double negative) pro-T cell. Study 32 B-cell Maturation, Activation, and Differentiation flashcards from Kenny S. on StudyBlue.